त्वत्कृते by that action of yours, सःअयम् this, मूलहरः very root destroyed, महान् major, अनर्थः disaster, निर्वृत्तः extermination, सर्वम् all, इदम् thus, राक्षसंकुलम् Rakshasa clan, त्वया by you, अनाथम् orphaned, कृतम् done

"By this major disaster of yours, the very root has been destroyed. With the extermination of the Rakshasas, the entire Rakshasa clan is orphaned now by your action."