कृते one who does, अप्रतिकुर्वतः by not rendering help in return, महान् great, धर्मलोपः हि is a violation of dharma, गुणवतः of a virtuous, मित्रस्य friend's, नाशे loss, महान् great, अर्थलोपश्च loss of wealth, अंस्तावच will result in destruction.

'Dharma is violated when we help not one who has helped. Loss of a virtuous friend leads to great loss of wealth. It results in destruction.